Prostate Enlargement | Medtick

Prostate Enlargement

What is it?

A non-cancerous growth (prostatic stromal and epithelial cells leading to the growth of prostatic tissue) of the prostate gland, it then presses against the bladder and urethra (the tube where urine flows) and affects the flow of urine leading to lower urinary tract symptoms (please note the size of the prostate does not always contribute to the severity of lower tract urinary symptoms, other factors i.e. urethral resistance, body changes need to also be considered).

  • Two types of bladder changes occur:
    • Increased urinary frequency and urgency
    • Worsen the urinary force stream
  • Symptoms can vary in range and does not increase the chance of prostate cancer or is serious to men’s health.

Diagnosis Tests

There are variety tests to confirm this condition from physical examinations to the  detecting levels of prostate-specific antigens in the blood (please note this test is not specific to detecting cancer of the prostate merely an indicator).

  • Ultrasonography (abdominal, renal, transrectal) and intravenous urography may also be included to determine bladder and prostate size and as well as to also check for hydronephrosis.
  • Cystoscopy (before surgery)

  • One test that should be considered is if a patient has predominant significant nocturia (urinating at night) and is awakened two or more times per night, a frequency volume chart (also called a voiding diary) covering 2-3 days is recommended
    • Nocturnal polyuria (ration of urine at night compared to day) is diagnosed when more than 33% of the 24-hour urine output occurs at night.
    • Patients with bothersome symptoms should aim for a urine output of 1L per 24 hours.

American Urological Association


Men who are carriers of BRCA 1 gene mutations and BRCA 2 gene mutations variants should have screening done as this can cause faster-growing aggressive cancers independent of age.

Cause

Syndromes

Vitamins, herbals and minerals


Symptoms

(Symptoms come and go, over a period of time)

Men only:

  • Anaemic (i.e. lack of oxygen in blood, due to lack of iron, folic acid or heavy blood loss)?
  • Blood in urine?
  • Difficult to start urinating and stop urinating?
  • General discomfort (muscle weakness), uneasiness or ill feeling (malaise) and/or fatigue (tiredness)?
  • High temperature greater than 38°C (100°F) or over and/or chills and sweats longer than 72hours?
  • Feeling bladder has not fully emptied after urinating making infections (cloudy-smelly urine, fever, nausea and vomiting, pain in abdomen) more likely?
  • Aching, painful muscles, muscle cramps/spasms/stiffness?
  • Joint stiffness and pain?
  • Increase thirst, heavy sweating and need to urinate frequently?
  • Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?
  • Pain in pelvis area, lower back?
  • Pain when urinating?
  • Strain to urinate due to weak flow?
  • Erectile dysfunction?

Complications /Information to beware of/General tips:

Medical Emergency Condition

And/or do not wait, phone for an ambulance if have or develop:

  • Sepsis
  • Dehydration symptoms
  • Unable to pass urine
  • Severe pain and swelling in abdominal region?
  • Symptoms of  Acute (short term) Prostatitis developed SUDDENLY:
    • Severe abdominal pain?
    • Frequent need to urinate?
    • High fever of  38°C (100°F) , feeling hot sweaty and clammy?
    • Nausea and vomiting?
    • Swollen scrotum?
    • Pain when urinating?
    • Difficult to start or stop urination?

This condition can lead to:

Methods to reduce lower urinary tract symptoms:

  • Avoid alcohol and caffeine
  • Avoid drinking fluids at bedtime, and drink smaller amounts throughout the day
  • Avoid taking decongestant and antihistamine medications (especially if one believes they have cold and flu symptoms)
  • Get regular exercise
  • Make a habit of going to the bathroom when the urge is present
  • Practice double voiding (empty the bladder, wait a moment, then try again)
  • Practice stress management and relaxation techniques

Medscape


Lifestyle advice

For many patients, lifestyle modifications can improve symptoms without the need for further intervention:

Firth J, Conlon C, Cox T, editors. Oxford Textbook of Medicine. Oxford University PressOxford 2020.doi:

10.1093/med/9780198746690.001.0001

  • Regularly practise pelvic floor exercises to strength the muscles that control urine flow;
Non-Surgical Treatment: Urinary Incontinence. NHS. 2023.https://www.nhs.uk/
  • Stop smoking to reduce the incidence of coughing, which can strain the pelvic floor muscle;
  • Avoid heavy lifting. This can put pressure on the pelvic floor muscles, increasing the risk of leaks.

10 Ways to Stop Leaks: Urinary Incontinence. NHS. 2023.
https://www.nhs.uk/conditions/urinary-incontinence/10-ways-to-stop-leaks
(accessed Aug 2023).

  • Reduce caffeine intake to limit irritation to the bladder;

Lohsiriwat S, Hirunsai M, Chaiyaprasithi B. Effect of caffeine on bladder function in patients with overactive bladder symptoms. Urol Ann. 2011;3:14. doi:10.4103/0974-7796.75862

  • Decrease alcohol consumption as alcohol acts as a diuretic;
  • Drink six to eight glasses of water per day. Limiting fluid intake can reduce bladder capacity and make incontinence worse;

Bradley CS, Erickson BA, Messersmith EE, et al. Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review. Journal of Urology. 2017;198:1010–20. doi:10.1016/j.juro.2017.04.097

  • Avoid constipation to prevent straining;
  • Lose excess weight to lessen pressure on the bladder;

Parsons JK, Sarma AV, McVary K, et al. Obesity and Benign Prostatic Hyperplasia: Clinical Connections, Emerging Etiological Paradigms and Future Directions. Journal of Urology. 2013;189. doi:10.1016/j.juro.2012.11.029


Treatment

  • The prostate is made up of smooth muscle controlled by the adrenergic nervous system, medication that block the alpha adrenergic receptors help with urethral resistance and improvement of obstructive voiding symptoms.
  • More non-invasive treatments [i.e. Prostatic Urethral Lift (PUL), Water Vapour Thermal Therapy] and invasive treatments (laser therapy, surgery, Photoselective Vaporisation) are available if medication does not help.

This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Prostate Enlargement in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

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References

  • The Pharmaceutical Journal, PJ, August 2023, Vol 311, No 7976;311(7976)::DOI:10.1211/PJ.2023.1.194315