Tumor Necrosis Factor Receptor Associated Periodic Syndrome

What is it?

Tumor Necrosis Factor Receptor Associated Periodic Syndrome is a rare genetic disease with episodes of recurrent fever; abdominal, chest, and muscle pain; red and swollen eyes; and a typical rash lasting for attacks last 7 to 21 days (average of 10 days).

This condition is part of Hereditary periodic fever syndromes, which are hereditary disorders that periodically cause episodes of fever and other symptoms that are not due to usual childhood infections or any other obvious cause.

Cause

Family history
Gene defect in a protein called tumor necrosis factor receptor (these are involved in our inflammation processes in our bodies)
Infection
Trauma
Strenuous exercise
Psychological stress

Source: Periodic Fevers

Symptoms

Periods of fever?
Swollen eyes?
Joint pain and stiffness?
Rash lasting longer than a week, from body to arms and legs?
Aching, painful muscles, muscle cramps/spasms/stiffness?
Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?
Chest pain?
Diarrhoea?
Swollen spleen?

Males:

Heavy aching pain in scrotum and/or groin?

Complications /Information to beware of/General tips:

This condition can lead to:

Kidney failure

This condition has been associated with:

Amyloidosis
Hernia (inguinal hernias)

This condition may show similar symptoms to:

Familial Mediterranean fever
PFAPA syndrome (Periodic fever, mouth ulcers, inflamed sore throat, and swollen nodes in neck)
Hereditary cryopyrin-associated periodic syndromes (cryopyrinopathies):
- Familial cold autoinflammatory syndrome (FCAS)
- Muckle-Wells syndrome (MWS)
- Neonatal-onset multisystem autoinflammatory disease (NOMID).
  - Episodes of fever, a rash, and joint pain are periodically triggered by cold temperatures.
Hyper-IgD syndrome – This syndrome causes fever, abdominal pain, headache, joint pain, a rash, and swollen lymph nodes.
PAPA syndrome – This syndrome causes inflamed joints, skin ulcers, and acne

www.msdmanuals.com

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Tumor Necrosis Factor Receptor Associated Periodic Syndrome in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

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Verywell Health
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